Producción Científica Profesorado

Diastereoselective alkylation of chiral glycinate derivatives containing the ?-phenylethyl group.



Rojas Lima, Susana

2011

Rodríguez-Garnica Cristina, López-Ruiz Heraclio,* Rojas-Lima Susana, Álvarez - Hernández Alejandro, Tapia-Benavides Rafael, García-López María Concepción. Diastereoselective alkylation of chiral glycinate derivatives containing the ?-phenylethyl group. Journal of the Mexican Chemical Society, 55(3), 148-153. (2011)


Abstract


Novel chiral glycinate derivatives (S)-6 and (S)-7 containing the a-phenylethyl group, were prepared and studied as potentialprecursors of enantiopure a-substituted-a-amino acids. In particular, the alkylation of enolate (S)-7-Li showed substantial (78:22 dr)stereoinduction by the N-(1-phenylethyl)benzamide chiral auxiliary.Addition of DMPU showed no appreciable effect upon the diastereoselectivity



Producto de Investigación




Artículos relacionados

3-Benzoyl-2-isopropyl-4-alkyloxazolidin-5-ones as Efficient and Inexpensive Sources of Enantiopure ?...

Synthesis of new homochiral 2,3-dialkylpiperazines derived from (R)-(?)-phenylglycinol

Synthesis, crystal structures, and quadratic nonlinear optical properties in a series of pushpull bo...

Preparation of N-aryl-substituted spiro-?-lactams via Staudinger cycloaddition

Phenylmethyl 2,3,4-tri-O-acetyl--D-fucopyranoside

Diastereoselective alkylation of chiral glycinate derivatives containing the ?-phenylethyl group.

Stereoselective addition of allylmagnesium chloride to the CN bond of [4.3.0] boron heterobicycles

Structural studies of spiroarsoranes derived from 2-aminophenols

Cathepsins X and B Can Be Differentiated through Their Respective Mono- and Dipeptidyl Carboxypeptid...

Synthesis and Study of Isomeric Benzo[1,4]oxazines and Benzothiazolines by NMR Spectroscopy and X-Ra...