Producción Científica Profesorado

Diastereoselective alkylation of chiral glycinate derivatives containing the ?-phenylethyl group.



Lopez Ruíz, Heraclio

2011

Rodríguez-Garnica Cristina, López-Ruiz Heraclio,* Rojas-Lima Susana, Álvarez - Hernández Alejandro, Tapia-Benavides Rafael, García-López María Concepción. Diastereoselective alkylation of chiral glycinate derivatives containing the ?-phenylethyl group. Journal of the Mexican Chemical Society, 55(3), 148-153. (2011)


Abstract


Novel chiral glycinate derivatives (S)-6 and (S)-7 containing the a-phenylethyl group, were prepared and studied as potentialprecursors of enantiopure a-substituted-a-amino acids. In particular, the alkylation of enolate (S)-7-Li showed substantial (78:22 dr)stereoinduction by the N-(1-phenylethyl)benzamide chiral auxiliary.Addition of DMPU showed no appreciable effect upon the diastereoselectivity



Producto de Investigación




Artículos relacionados

Enantioselective synthesis of ?-amino acids. Part 11: Diastereoselective alkylation of chiral deriva...

Synthesis of New Chiral Derivatives of N,N?-Dimethylpropyleneurea (DMPU) and Examination of Their In...

Diastereoselective alkylation of chiral glycinate derivatives containing the ?-phenylethyl group.

Further insight into three center hydrogen bonding. Participation in tautomeric equilibria of hetero...

Preparation of N-aryl-substituted spiro-?-lactams via Staudinger cycloaddition

Synthesis of nitrogen-, oxygen- and sulphur-containing tripodal ligands with a trimethylbenzene core...

Aroylthioureas: new organic ionophores for heavy-metal ion selective electrodes

New boronates prepared from 2,4-pentanedione derived ligands of the NO2 and N2O2 type comparison to...

Diastereoselective alkylation of chiral glycinate derivatives containing the ?-phenylethyl group.

Preparation of Seven- and Eight-Membered Boron Heterocycles from Different Salen Ligands and Arylbor...