Diastereoselective alkylation of chiral glycinate derivatives containing the ?-phenylethyl group.
Lopez Ruíz, Heraclio
2011
Rodríguez-Garnica Cristina, López-Ruiz Heraclio,* Rojas-Lima Susana, Álvarez - Hernández Alejandro, Tapia-Benavides Rafael, García-López María Concepción. Diastereoselective alkylation of chiral glycinate derivatives containing the ?-phenylethyl group. Journal of the Mexican Chemical Society, 55(3), 148-153. (2011)
Abstract
Novel chiral glycinate derivatives (S)-6 and (S)-7 containing the a-phenylethyl group, were prepared and studied as potentialprecursors of enantiopure a-substituted-a-amino acids. In particular, the alkylation of enolate (S)-7-Li showed substantial (78:22 dr)stereoinduction by the N-(1-phenylethyl)benzamide chiral auxiliary.Addition of DMPU showed no appreciable effect upon the diastereoselectivity
Artículos relacionados
O-benzyl-N-(2-furoyl)thiocarbamate
Ylidaddukte der Penteltrichloride
Et3B, an Efficient Mediator for Xanthate Transfer Based Radical Processes
A practical access to acyl radicals from acyl hydrazides
Structural studies of spiroarsoranes derived from 2-aminophenols