Producción Científica Profesorado

Voltammetric Quantification of Diclofenac Using a Modified CPE Enriched With TiO2 Nanoparticles and MWCNT



Alvarez Romero, Giaan Arturo

2021

Miriam Franco-Guzmán, Luis Humberto Mendoza-Huizar, Gabriela Roa-Morales, Carlos Andrés Galán-Vidal and Giaan Arturo Álvarez-Romero, Voltammetric Quantification of Diclofenac Using a Modified CPE Enriched With TiO2 Nanoparticles and MWCNT. J. Electrochem. Soc., 2021, 168, 037502


Abstract


This work describes the development of a voltammetric methodology based on a carbon paste electrode enriched with multiwalled carbon nanotubes and TiO2 nanoparticles, for the electrochemical quantification of diclofenac. All stages of the methodology were optimized by a Box-Behnken experimental design. The electrochemical behavior of diclofenac was studied by cyclic voltammetry. Results showed that the oxidation of diclofenac is favored by the presence of both MWCNT and TiO2 nanostructures since a considerable increase in the anodic peak current is observed when compared to a that obtained with a bare carbon paste electrode. Under the optimal values found and with the appropriate statistical analysis, a LOD of 0.33 ?M, a LOQ of 1.11 ?M, a linear concentration range from 1.1 × 10?6 to 5 × 10?3 M (R2 = 0.9958), and a sensitivity of 0.487 ?A.?M?1 were found. The electrode's response was precise as the reproducibility resulted to be 4.39% (%RSD). Finally, a study of possible interferences was performed, along with the quantification of diclofenac in pharmaceutical samples by the proposed voltammetric methodology. The voltammetric method was validated by comparing the results with those obtained with the UV?vis spectrophotometric method.






Artículos relacionados

Development of a novel composite sensor based on doped pyrrole selective to nitrate ions

Kinetics of Polypyrrole Films Doped with Sulphate Ions Electrodeposited Over Graphite - Epoxy Resin ...

Potentiometric Behavior of Diverse Polypyrrolesulphate Films Electro Synthesized on Graphite Epoxy ...

Synthesis, characterization, and crystal structures of n-alkyldiorganodithiophosphates RS2P(OC6H4)2

Metal content evaluation and its effect on the stability of anthocyanins

Development of a novel nitrate-selective composite sensor based on doped polypyrrole

Synthesis and crystal structures of cis-palladium(II) and cis-platinum(II) complexes containing dipy...

Characterization of Main Anthocyanins Extracted from Pericarp Blue Corn by MALDI-ToF MS

Renewable stationary phase liquid magnetochromatography: determining aspartame and its hydrolysis pr...

Characterization of Main Anthocyanins Extracted from Pericarp Blue Corn by MALDI-ToF MS