Producción Científica Profesorado
Enantioselective Synthesis of Either Enantiomer of ?-Alkyl-?-hydroxy-?-phenylacetic Acids Using Chiral Auxiliaries
Peréz Estrada, Salvador
2005
Pérez-Estrada, S.; Lagunas-Rivera, S.; Vargas-Díaz, M. E.; Velázquez-Ponce, P.; Joseph-Nathan, P.; Zepeda, L. G. ?Enantioselective Synthesis of Either Enantiomer of ?-Alkyl-?-hydroxy-?-phenylacetic Acids Using Chiral Auxiliaries? Tetrahedron: Asymmetry 2005, 16, 1837-1843, DOI: 10.1016/j.tetasy.2005.03.032.
Abstract
The enantioselective synthesis of either enantiomer of ?-alkyl-?-hydroxy-?-phenylacetic acids was achieved by using 2-acyloxathianes 1a?c and the mixed acyl-S,O-acetals 7 and 8 as chiral auxiliaries, which can straightforwardly be prepared from (1R)-(?)-myrtenal. This procedure allowed the preparation of the title compounds in >95% enantiomeric excess (ee).
