2017
Daniel Mendoza-Espinosa, Alejandro Alvarez-Hernández, Deyanira Angeles-Beltrán, Guillermo E. Negrón-Silva, Oscar R. Suárez-Castillo, and José M. Vásquez-Pérez,Inorg. Chem., 2017, 56(4), 2092-2099DOI: 10.1021/acs.inorgchem.6b02778
Abstract
Following a copper catalyzed alkyne azide cycloaddition (CuAAC)and N-alkylation protocols, we report the preparation of a hybrid N-heterocyclic/mesoionic [NHC(H+)-MIC(H+)][2I]2? salt (1) in high yields. The treatment ofsalt 1 with Cu2O and KI yields a second hybrid NHC/MIC proligand featuring atetraiodocuprate anion [NHC(H+)-MIC(H+)][Cu2I4]2? (2). Through selectivedeprotonation and metalation, both salts 1 and 2 can generate either the chelateheterodicarbene complexes (3) with the rare [NHC(M)MIC]+[MX2]? generalformula (M = PdII, RhI) or NHC-anchored/pendent triazolium species (4)[NHC(M)-MIC(H+)]. If the triazolium moiety of type 4 complexes isdeprotonated with KHMDS in the presence of a second metal center, a seriesof heterobimetallic complexes of the type [NHC(M)-MIC(M?)] (5) areachieved. Interestingly, the reaction of salt 2 with KHMDS yields the bimetalliccopper heterodicarbene (6) which can be a useful transfer reagent for the preparation of type 3 complexes. A variety of syntheticroutes for the preparation of complexes 3?5 and their full characterization in solution and in the solid state will be discussed.
Conformational studies on indole alkaloids from Flustra foliacea by NMR and molecular modeling
Synthesis of Indolylindolines Mediated by tert-BuNH2
Absolute configuration determination of 2-(2-oxo-3-indolyl)acetamide derivatives
Transesterifications mediated by t-BuNH2
Regioselective Synthesis of 3-Indolyl(alkoxy)acetates
Role of lipid peroxidation in biliary obstruction in the rat
Stereochemical assignment of naturally occurring 2,3-epoxy-2-methylbutanoate esters
13C NMR and crystallographic evidence of push-pull effects in furoindolic ?-enamino esters