2012
Gonzalez-Juarez, D. E., García-Vazquez, J. B., Zuñiga-García, V., Trujillo-Serrato, J. J., Suárez-Castillo, O. R., Joseph-Nathan, P., & Morales-Ríos, M. S. (2012). Stereochemistry modulates the catalytic hydrogenolysis of nitrile-substituted cyclopropanes Tetrahedron 68, 7187-7195.
Abstract
The study of Raney-Ni catalyzed chemo- and regioselective hydrogenolysis of diastereomeric nitrile-substituted spirocyclopropyloxindoles is presented. The chemoselectivity outcome of the reaction is remarkably influenced by the relative stereochemistry of the nitrile-substituted spirocyclopropyloxindoles. Chemo- and high regioselective cyclopropane ring-opening occurs from the syn diastereomers to give the corresponding 3-propylacetamide derivatives. X-ray crystallographic studies together with DFT model chemistry calculations indicate that chemo- and regioselectivity are directly dependent on the bond length asymmetry of the cyclopropane ring
Synthesis of Acetamido(indol-3-yl)propanol Derivatives
Unimolecular rearrangements of ketene-O,O-acetals and fragmentations occurring in the gas phase
Conformational studies on indole alkaloids from Flustra foliacea by NMR and molecular modeling
One-potsynthesis of conformationallyrestrictedspirooxindoles