2002
Conformational studies on indole alkaloids from Flustra foliacea by NMR and molecular modeling. Morales-Ríos Martha S., Santos-Sánchez Norma F., Suárez-Castillo Oscar R. DOI: 10.1002/mrc.1080
Abstract
1H and 13C NMR assignments for 1a4a and 1b4b were obtained using HSQC, HMBC and NOESY techniques. Differences and ambiguities from literature assignments are reconciled. For the pyrrolidine C-ring, the combined use of NMR spectroscopy and molecular mechanics calculations revealed that this ring exists in a dynamic conformational equilibrium between twist (2T1) and envelope-twist (1E1T2) conformations. In chloroform-d1, the 1H NMR coupling constants indicate that the pyrrolidine ring is biased in favor of the envelope-twist conformation. Steric requirements of the N-prenyl group enhanced the envelope-twist (1E1T2) conformation populations.
Stereochemical assignment of naturally occurring 2,3-epoxy-2-methylbutanoate esters
Regioselective Synthesis of 3-Indolyl(alkoxy)acetates
Unimolecular rearrangements of ketene-O,O-acetals and fragmentations occurring in the gas phase
13C NMR and crystallographic evidence of push-pull effects in furoindolic ?-enamino esters
Configuration, stereodynamics and crystal structure of 3-substituted-2-oxofuro[2,3-b]indoles
One-potsynthesis of conformationallyrestrictedspirooxindoles
Role of lipid peroxidation in biliary obstruction in the rat
Trapping enols of esters and lactones with diazomethane
Synthesis of Bromoindole Alkaloids from Laurencia brongniartii